Study on praxiology and mechanisms of animal models of tic disorders.

CHE Li-chun; LIU Xiu-mei; CHEN Lang; LIU Shi-guo; YI Ming-ji.

doi:10.11852/zgetbjzz2016-24-12-12

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Chinese Journal of Child Health Care ›› 2016, Vol. 24 ›› Issue (12) : 1274-1277. DOI: 10.11852/zgetbjzz2016-24-12-12

Study on praxiology and mechanisms of animal models of tic disorders.

CHE Li-chun¹,LIU Xiu-mei²,CHEN Lang³,LIU Shi-guo⁴,YI Ming-ji¹.

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Abstract

Objective To observe the behavior and evaluate the levels of dopamine(DA) and hydroxytryptaminel(5-HT) in striatum and plasma in rat models of tic disorder(TD) induced by iminodipropionitrile(IDPN) or 1-2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI),and provide the evidence of selecting rat models reasonably. Methods The rats of IDPN inducement were intraperitoneally injected IDPN,and the rats of DOI inducement were intraperitoneally injected DOI.The activity scale scores,stereotypy scale scores and classified stereotypy scale scores were observed and recorded by double-blind method.The levels of DA and 5-HT in striatumin and plasma of the rat models of TD induced by IDPN or DOI were observed by ELISA,and the mechanism of the rat models was discussed. Results The activity scale scores,stereotypy scale scores in the IDPN and DOI inducement groups were higher than those in the control group (P<0.05).The scores of circling and choreoathetoid movement of rat in the IDPN inducement group were higher than those in the DOI group and control group (P<0.05).The scores of paw-to-mouth movements and self-gnawing of rat in the DOI inducement group were higher than those in the IDPN group and control group (P<0.05).The DA concentrations in plasma and striatum were higher in the IDPN model group (5.70±3.12,137.45±20.14) than those in the control group(0.32±0.12,68.13±12.34)and DOI model group(1.01±0.74,88.56±21.30) (F=13.43~8.6,P<0.05).The 5-HT concentration in striatum was found to be lower in the DOI model group(56.83±34.72) compared to that in the control group(109.14±14.05) and IDPN model group(72.52±10.03)(F=3.65,P<0.05). Conclusions The generalized tics are obviously observed in the IDPN models.The partial tics are obviously observed in the DOI models.The decreasing DA concentration in striatum of the IDPN models could lead to tic disorders.The exciting 5-HT receptor of the DOI models could lead to tic disorders.

Key words

tic disorder / animal models / iminodipropionitrile / 1-2,5-dimethoxy-4-iodophenyl-2-aminopropane / praxiology / dopamine / hydroxytryptamine

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CHE Li-chun,LIU Xiu-mei,CHEN Lang,LIU Shi-guo,YI Ming-ji.. Study on praxiology and mechanisms of animal models of tic disorders.[J]. Chinese Journal of Child Health Care. 2016, 24(12): 1274-1277 https://doi.org/10.11852/zgetbjzz2016-24-12-12

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