Objective To analyse the etiology and clinical outcome of infantile cholestasis. Method The clinical data were collected of 3 weeks years old to 3 months years old infants with cholestasis in our hospital from January 2011 to September 2015.The causes and clinical features of the disease were analyzed,and to track the clinical prognosis. Result Main cause of 1 360 cases with cholestasis were anatomic anomalies (316 cases,23.23%),infection (540 cases,39.70%),inborn errors of metabolism(145 cases,10.66%),unexplained (350 cases,25.74%),others (9 cases,0.66%).The three most common reason were cytomegalovirus infection (485 cases,35.66%),biliary atresia (301 cases,22.13%) and Citrin deficiency (96 cases,7.06%).1 193 cases (87.72%) were improved and discharged,166 cases (12.20%)were gived up treatment,and 1 case (0.07%) were dead. Conclusion The etiology of infantile cholestasis is complicated.Incidence of biliary atresia,cytomegalovirus,citrin deficiency in cholestatic jaundice is high,early etiology diagnosis is beneficial to improve the clinical outcome.
Key words
cholestasis /
cytomegalovirus /
biliary atresia /
citrin deficiency
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