Objective To explore the infuencing factors of neonatal respiratory distress syndrome (NRDS) combined bronchopulmonary dysplasia (BPD),and to provide reference for prevention and treatment. Methods 200 cases of children with NRDS,were divided into BPD groups and non-BPD group depending on whether the merger bronchopulmonary dysplasia (BPD).Summarize clinical data of children,risk factors of BPD were analized using univariate analysis and Logistic multivariate analysis method. Results In 200 HMD children,a total of 48 children with BPD,the prevalence was 24.00%.With increasing gestational age,BPD prevalence declined.With the increase of birth weight,BPD prevalence declined.Univariate analysis showed that hospital stay,incidence of pulmonary hemorrhage,birth weight,gestational age,duration of mechanical ventilation,Apgar score was significantly different between BPD group and non-BDP group (P<0.05);multivariate analysis showed that gestational age,weight,pulmonary hemorrhage were risk factors of BPD (P<0.05). Conclusion The gestational age and weight are important risk factors for BPD,preventive measures should be given in clinical,and treatment of lung primary disease is important in preventing BPD.
Key words
neonatal respiratory distress syndrome /
bronchopulmonary dysplasia /
newborns /
risk factors
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References
[1] 陈思红,文梦灵,黄友妮,等.固尔苏联合鼻塞式持续气道正压通气治疗新生儿肺透明膜病的护理[J].护士进修杂志,2016,31(1):45-46.
[2] Grappone L,Messina F.Hyaline membrane disease or respiratory distress syndrome? A new approach for an old disease[J].Journal of Pediatric and Neonatal Individualized Medicine (JPNIM),2014,3(2):e030263.
[3] Bancalari EH,Jobe AH.The respiratory course of extremely preterm infants:A dilemma for diagnosis and terminology[J].The Journal of Pediatrics,2012,161(4):585-588.
[4] 金汉珍,黄德珉,官希吉.实用新生儿学[M].2版.北京:人民卫生出版社,1996:350,376.
[5] Morris I,Adappa R.Minimizing the risk of respiratory distress syndrome[J].Paediatrics and Child Health,2012,22(12):513-517.
[6] Gough A,Linden MA,Spence D,et al.Executive functioning deficits in young adult survivors of bronchopulmonary dysplasia[J].Disability and Rehabilitation,2015,37(21):1940-1945.
[7] 徐发林,张彦华,段佳佳,等.不同分度早产儿支气管肺发育不良临床高危因素[J].中华实用儿科临床杂志,2013,28(14):1073-1076.
[8] Mirza H,Ziegler J,Ford S,et al.Pulmonary hypertension in preterm infants:prevalence and association with bronchopulmonary dysplasia[J].The Journal of Pediatrics,2014,165(5):909-914.e1.
[9] Baker CD,Abman SH,Mourani PM.Pulmonary hypertension in preterm infants with bronchopulmonary dysplasia[J].Pediatric Allergy,Immunology,and Pulmonology,2014,27(1):8-16.
[10] Gadhia MM,Cutter GR,Abman SH,et al.Effects of early inhaled nitric oxide therapy and vitamin A supplementation on the risk for bronchopulmonary dysplasia in premature newborns with respiratory failure[J].The Journal of Pediatrics,2014,164(4):744-748.
[11] Mourani PM,Sontag MK,Younoszai A,et al.Early pulmonary vascular disease in preterm infants at risk for bronchopulmonary dysplasia[J].American Journal of Respiratory and Critical Care Medicine,2015,191(1):87-95.
[12] Fischer HS,Bührer C.Avoiding endotracheal ventilation to prevent bronchopulmonary dysplasia:a meta-analysis[J].Pediatrics,2013,132(5):e1351-e1360.
[13] Kinsella JP,Cutter GR,Steinhorn RH,et al.Noninvasive inhaled nitric oxide does not prevent bronchopulmonary dysplasia in premature newborns[J].The Journal of Pediatrics,2014,165(6):1104-1108.e1.
[14] 严洁,何蓉,肖志辉,等.早产儿支气管肺发育不良发生的高危因素及新生儿急性生理学评分对其的预测价值[J].中华实用儿科临床杂志,2013,28(14):1080-1082.
[15] 彭磊,乐功芳,陈绪萍,等.早产儿支气管肺发育不良的高危因素及防治对策[J].临床肺科杂志,2015,20(1):92-94,95.
[16] 欧伟明,张金凤,黄润忠,等.早产儿支气管肺发育不良的高危因素及与 PAI-1的关系[J].实用医学杂志,2014,30(18):2952-2954.