Objective To explore the diagnostic value of ultrasound in neonatal brain injury. Methods Totally 80 cases with perinatal asphyxia history,were selected from May 2013 to August 2015 in our pediatric hospital,prenatal ultrasound had excluded intracranial congenital structural abnormalities,cranial ultrasound was conducted at 72 h of birth,to detecte cerebral artery and middle cerebral artery blood flow dynamics from the temporal anterior fontanelle,the main parameters were peak systolic velocity (Vs),diastolic velocity (Vd) and resistance index (RI).At the end of 24 hours,head MRI was used as the gold standard to compare with the ultrasound results. Results 80 cases of children were prompted MRI brain injury,showed multifocal distribution.62 cases of ultrasound showed varying degrees of brain damage,the positive rate was 77.5%. Conclusions Early ultrasound of neonatal cranial can detect structural and hemodynamic changes in cerebral tissue,provide important information for clinical diagnosis.