Objective To analyse the intervention effect of supplementation on children′s nutrition hemoglobin (Hb) and iron deficiency in infants of 6~24 months,in order to provide a scientific basis for the prevention of nutritional anemia. Methods The survey was conducted according to random sampling in three counties of Heng,Lingshan and Binyang Courty where with a high incidence of iron deficiency anemia in Guangxi.Questionnaire survey and measuring Hb value were given to four groups aged 12~24 months infants excluding infants with thalassemia before,4 months later and 8 months after the intervention.All A,B,C,D groups′ intervention program were given normal feed,add nutrition combine health education,nutrition,health education and none intervention to A,B,C groups,respectively. Results Each month old infants′ Hb after 4 months later and 8 months later were higher than those before intervention (P<0.05).8 months after the intervention,the Hb of the intervention group was higher than that of the control group showed in 12~24 month infants (t=2.78,P=0.006).Both A/B groups were higher than C and D groups (analysis with LSD method,P<0.05). Conclusion Supplementary nutrient for children can improve hemoglobin value,and it is conducive to improve the status of anemia in infants.