Objective To explore the different feeding methods of baby immune function,and guide baby appropriate feeding practices. Methods Totally 69 cases healthy term infants were selected who born from Xiaogan Affiliated Hospital of Wuhan University of Science and Technalogy during the time from January 2014 to January 2015 as research objects.According the different feeding methods to dividing them into three groups,breastfeeding group(group Ⅰ),partial breastfeeding group(group Ⅱ)and artificial group(group Ⅲ),whom had regularly outpatient follow-up visits respectively in 1,3,6 months age and 12 months age.The occurrence of respiratory tract infection,test blood interleukin-6 (IL-6),blood IgG,IgM and IgA level in peripheral blood were observed,and the test results were analyzed. Results Group Ⅰ and group Ⅲ had obvious difference in the number of recurrent respiratory tract infections within 12 months age (χ²=5.463,P=0.019);The content of blood IgG had significant differences (P<0.05)in 6 months age,that of group Ⅰ(7.189±1.525) was higher than that of group Ⅱ (6.136±1.105) and group Ⅲ (5.240±1.065);The content of blood IgM had significant differences (P<0.05)in 6 months age,that of group Ⅰ(0.784±0.268) higher than that of group Ⅱ(0.675±0.189) and group Ⅲ(0.527±0.190).And the blood IgM content between group Ⅰ(1.485±0.427) and group Ⅱ(1.392±0.452)had no significant differences in 12 months age,but both groups had obvious differences compared with group Ⅲ(P<0.05);The content of blood IgA had significant differences in 1,3,6 and 12 months (P<0.05);The content of blood interleukin-6 had significant differences between three groups during 6 months age,as follows group Ⅰ(14.782±2.487),group Ⅱ(12.520±2.014) and group Ⅲ(11.051±1.904);It had no obvious differences (P>0.05) in 12 months age between group Ⅰ (16.285±3.112) and group Ⅱ(15.854±3.281),but both had significant differences compared with group Ⅲ(12.058±2.840)(P>0.05). Conclusions Feeding methods have effects on infants immune function,especially breastfeeding can increase infants immunity and reduce their repeated respiratory infection prevalence.When mothers have no enough breast milk,timely adding formula feeding can prevent the baby immune suppression.