Association of the 48 bp variable number of tandem repeat polymorphism of dopamine D4 receptor gene with attention deficit hyperactivity disorder:a Meta-analysis.

WU Ling; WANG Ling-hua; CHA Cai-hui; OU Wan-xing

doi:10.11852/zgetbjzz2016-24-09-16

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Chinese Journal of Child Health Care ›› 2016, Vol. 24 ›› Issue (9) : 946-950. DOI: 10.11852/zgetbjzz2016-24-09-16

Association of the 48 bp variable number of tandem repeat polymorphism of dopamine D4 receptor gene with attention deficit hyperactivity disorder:a Meta-analysis.

WU Ling¹, WANG Ling-hua², CHA Cai-hui², OU Wan-xing²

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Abstract

Objective To explore the association of the 48 bp variable number of tandem repeat(VNTR) polymorphism at exon 3 of dopamine D4 receptor (DRD4) gene with attention deficit hyperactivity disorder (ADHD). Methods The Chinese and English references about the association between 48 bp VNTR polymorphism of DRD4 gene and ADHD were retrieved through Chinese National Knowledge Infrastructure (CNKI),Wanfang,Weipu,Chinese Biomedical Database( CBM),PubMed,Cochrane Library,EBSCO,Ovid,Springer databases,until October 30,2015.A Meta-analysis was used to systematically analyze the literatures. Results A total of 20 studies were included in the final Meta-analysis,enrolling a total of 3 658 ADHD cases and 6 272 controls.The Meta-analysis showed that the frequencies of DRD4 gene 48 bp 4 repeat (4R),7 repeat (7R) and long repeat had statistical differences between ADHD group and the control group in the global group;the frequencies of DRD4 gene 48 bp had not statistical difference between ADHD group and the control group in the Asia group ;the frequencies of DRD4 gene 48 bp 4R,7R,short repeat and long repeat had statistical differences in the non-Asia group. Conclusions The Meta-analysis revealed that the DRD4 48 bp 4R,7R and long repeat have association with ADHD in the global group;The DRD4 48 bp 4R,7R,short repeat and long repeat have association with ADHD in the global group in non-Asia group.There is no statistical difference between ADHD group and the control group in the Asia group.

Key words

attention deficit hyperactivity disorder / dopamine D4 receptor gene / variable number of tandem repeat / Meta analysis / children

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WU Ling, WANG Ling-hua, CHA Cai-hui, OU Wan-xing. Association of the 48 bp variable number of tandem repeat polymorphism of dopamine D4 receptor gene with attention deficit hyperactivity disorder:a Meta-analysis.[J]. Chinese Journal of Child Health Care. 2016, 24(9): 946-950 https://doi.org/10.11852/zgetbjzz2016-24-09-16

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