Objective To understand the demographic distribution of preschool children's generalized anxiety disorder (GAD),and investigate the relation between family nurture environment and social life abilities,and provide the ways to protect the somatic and mental health of preschool children. Methods A total of 969 preschoolers aged 3~6 were selected and their parents were asked to complete the "Spence Preschool Children's Anxiety Scale","Infant-Junior Middle School Students' Social Life Abilities Scale","Family Nurture Environment Scale".The data were analyzed by means of t-test and Logistic regression analysis. Results The relevance ratio on the GAD was 12.8%,and the relevance ratio in males (14.48%) was higher than that in females (10.96%).Gender and grade had no significant differences (P>0.05).The item of social life ability showed significant differences among the independent living (t=3.495,P<0.05),movement (t=2.973,P<0.05),operations (t=4.285,P<0.05),attending collective activities (t=3.433,P<0.05),self-management (t=3.94,P<0.05).In the family nurture environment scale,the two groups had significant difference in aspects of language/cognitive (t=4.444,P<0.05),emotional warmth/self expression (t=5.234,P<0.05),and social adaptation/self management (t=5.394,P<0.05),ignore/interference/punishment (t=-6.909,P<0.05),to participate in activity diversity/game (t=5.935,P<0.05),the environment/atmosphere (t=4.001,P<0.05). Conclusions Generalized anxiety and other comorbid anxiety are very common in preschool children,preschool children's generalized anxiety associated with social life ability,family nurture environment.Children's anxiety can be prevention and early intervention by raising consultation on preschool children's parents.