Objective To explore the clinic significance of sFas/sFasL in serum of children with asthma. Methods A total of 67 children with asthma (asthma group) and 40 healthy children (healthy control group) were selected,sFas,sFasL in their serums were detected by ABC-ELISA. Results Compared with healthy control group,the sFas and sFasL in serum of asthma group were elevated markedly(P<0.01). Conclusion The sFas,sFasL in children with asthma were higher than healthy children,sFas/ sFasL maybe take part in the pathological process of asthma.
Key words
asthma /
children /
SFas /
FasL /
apoptosis
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 杨平满,王悦虹,周建英.Fas/FasL与支气管哮喘[J].国际呼吸杂志,2011,31(19):1475-1477.
[2] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治常规(2016年版)[J].中华儿科杂志,2016,54(3):167-170.
[3] 张晶洁,除荣谦,王俊宏,等.细胞凋亡相关因子与咳嗽变异性哮喘关系的研究[J].长春中医药大学学报,2012,28(1):139-141.
[4] QIN Yi-ming,SHENG Jian-hua,XIONG Huai-min,et al.Proliferation and activation induced cdl death of CD4+ T cells in childhood asthma[J].International Journal of Pediatrics,2012,39(4):424-427.
[5] 袁岳沙,陈杰,王琳,等 哮喘儿童外周血T淋巴细胞Fas/FasL的表达及其意义[J].时珍国医国药,2008,19(9):2178-2179.
PDF(256 KB)
