Objective To investigate the therapeutic effects on premature infant apnea by the two different treatments of the nasal synchronization intermittent positive pressure ventilation (NSIPPV) and nasal continuous positive airway pressure (NCPAP). Methods NSIPPV group included 40 cases of frequent apnea on premature infants with gestational age≤34 weeks treated in Northwest Women and Children Hospital during the period from January 1,2015 to December 31,2015.And NCPAP group included randomly selected 40 cases of frequent apnea on premature infants with gestational age≤34 weeks treated in Northwest Women and Children Hospital during the period from January 1,2014 to December 31,2014.There were no significant differences in their gestational ages at birth and birth weights.The two groups were given comprehensive treatments and the effects were observed. Results NSIPPV group had higher efficiency (P<0.01).The two groups were respectively given assisted ventilation for 1 h,12 h,24h,48h,and there were significant differences in pH,PCO₂,PO₂ indicator (P<0.01).There were significant differences between the two groups in the total ventilation time and total oxygen exposure time (P all<0.01).Rate of switched to intubation and the probability of mechanical ventilation of NSIPPV group after treatment failure was significantly less than that of NCPAP group (P<0.01).The NSIPPV probability of air leak was lower than NCPAP (P<0.01). Conclusion NSIPPV is more effective than NCPAP on preterm infants with frequent apnea,blood gas results were improved significantly.The probabilities of intubation and mechanical ventilation,air leak are reduced.The overall time assisted ventilation are also reduced.