Objective To analyze the main causes and early comprehensive intervention effects of the patients with Global developmental delay (GDD),and determine the in neurobehavioral development prognosis of them. Methods Totally 33 cases GDD hospitalized children with comprehensive intervention in the GDD were early intervention group,31 non-hospitalized cases that were for only the family intervention without comprehensive intervention,were the control group.The etiology was analyzed,and individual treatment was plan designed according to different etiology.Before and after the intervention,the GESELL Developmental Scale was used to determine the developmental quotient(DQ) for the statistical analysis,and the efficacy evaluation. Results Before intervention,there was no significant difference between the two groups.6 months later,the DQ of the intervention group was (72.20±15.56),which was significantly higher than that (59.98±14.61) before intervention and that (62.51±13.95) of the control group,the effect of the intervention group was significantly better than the control group(P<0.05),there were statistically significant differences.Neonatal hypoxic-ischemic encephalopathy (HIE),premature birth,intrauterine growth retardation and neonatal asphyxia were the common causes of GDD.The DQ in GDD children with single pathogenic factor was better than that in children with multiple factors. Conclusion s Comprehensive early intervention and individual treatment plan can significantly improve the DQ and the prognosis of the children with GDD.Strengthening perinatal health care has great significance to prevent and treat the GDD.