Objective To popularize the knowledge of attention-deficit hyperactivity (ADHD) disorder and teach the basic ways of behavior therapy for teachers and parents by medicine combine with education,and thus to improve the medication adherence and remission rate of ADHD. Methods In Jing'an and Putuo district of Shanghai,a random stratified sampling of 2 primary school in large,medium and small school according to the scale,one as control group,another as intervention group,and a total of 5 326 students from one to three grade were screened with Teacher Rating Scale (TRS) and Parent Symptom Questionnaire (PSQ).The positive were informed by "the investigator through telephone to be taken to the designated hospital by parents.Diagnosis was made according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition" (DSM-Ⅴ) diagnostic criteria.The Suanson Nolan and Pelham,Version Ⅳ Scale (SNAP-Ⅳ) scale was used for baseline assessment and function assessment after 6 months. Results There were 45.4% teachers and 30.2% parents who thought that ADHD was a disease before training; and there were 73.1% teachers and 59.3% parents after training (P<0.01);There were 32.6% teachers and 20.2% parents who thought that ADHD need medication before training,and there were 57.3% teachers and 41.5% parents after training (P<0.01).There were 68.7% students in intervention group and 34.4% in control with medication for 6 months.After 6 months of intervention,the remission rate was 59.6% in intervention group and 31.1% in control group (P<0.01).The factors influencing the medication adherence were training of parent,training of teacher,the family income,medical treatment charge of payment.The factors influencing remission rate were training of teacher,training of parents,age,distance of medical treatment. Conclusion The modle of medicine combine with education improves the popularity of ADHD for teachers and parents,and meanwhile improves medication adherence and remission rate significantly.