Objective To investigate the combination between the electroencephalography(EEG) and the hyperbilirubinemia of full-term newborn by the long term video-electroencephalography (VEEG) monitoring,and to evaluate the clinical value of the long term (VEEG) monitoring in the prognosis judgment of hyperbilirubinemia of full-term newborn. Methods EEG was studied for 42 full-term newborns without hyperbilirubinemia and nervous system disease,and 98 full-term newborns with hyperbilirubinemia in the first week.And they were assessed for EEG and neurological development three times(postnatal 15 days,1 and 3 months).A statistical method of rank-sum test was adapted in investigate relationship of EEG,serum bilirubin and prognosis judgment. Results 1)There were significant differences in EEG Results among the serum bilirubin level.The abnormal rate of EEG was related to the increase of serum bilirubin level.Especially EEG Results had significant differences of serum bilirubin level among the normal,moderate and severe groups,and between the mild,moderate and severe group.2)The EEG Results were valuable to hyperbilirubinemia prognosis judgment,and with increase of the degree of EEG abnormality,the prognosis was not optimistic,especially the neonates of severe abnormal EEG with hyperbilirubinemia and the incidence of sequelae was significantly higher than that of EEG Results in both normal and mild abnormal neonates.Conclusions The long term video-electroencephalography monitoring is combined with serum bilirubin level,it is not only reflect the extent of the damage of hyperbilirubinemia brain function,but also as the early prognosis judgment of an important method.The method is simple,convenient and economic.One of the routine method can be used as the severity of brain injury induced by neonatal hyperbilirubinemia and prognosis.