Objective To investigate the influence of the systematic intervention management for neural developmental and the incidence of cerebral palsy of high-risk infants with brain damage. Methods A total of 198 full-term brain injury high-risk infants in the First Affiliated Hospital of Bengbu Medical College neonatal intensive care unit (NICU) were selected and divided into intervention group (n=103) and control group (n=95) according to the parents intend.Two groups were given conventional treatment and care.On this basis,systematic early intervention was given in intervention group according to the hospital-family management mode.Differences of the incidence of abnormal muscle tone and abnormal primitive reflex were compared in two groups of high-risk infants at 3,6,12,18 months.Besides,differences of developmental quotient (DQ) and the incidence of cerebral palsy were compared in two groups of high-risk infants at 6,12,18 months. Results The incidences of abnormal primitive reflex and abnormal muscle tone of 3-months-old infants in two groups had no obvious differences (P>0.05).In terms of 6,12,18-months-old,they were obviously lower in the intervention group than those in the control group.Also,the incidence of cerebral palsy was significantly lower than the control group,difference was statistically significant(P<0.05 or <0.01).In the case of infants at 6,12,18 months,MDI and PDI score in intervention group were obviously higher than those in control group(P<0.01 or <0.001). Conclusion Systematic intervention management helps promote neural development,improve the level of mental development,and reduce the incidence of cerebral palsy of brain injury high-risk infants.