Objective To investigate the distribution of rs10783826,one single nucleotide polymorphisms (SNPs) in the coding-region of GLI1 gene,in Kunshan area,and determine the relationship between GLI1 gene and congenital heart disease (CHD). Methods Genotypes of the SNP were analyzed in 90 CHD patients and 90 normal controls by Denatured High Performance Liquid Chrom atography (DHPLC) and sequencing from August 2011 to May 2013.χ2 test was applied to analyze the genotype frequency and allele frequency be tween CHD groups and control groups. Results The rs10783826 of GLI1 gene was not statistically different between the CHD group and the control group(χ2=0.75,P=0.68),and the T allele carriers had no statistical difference between G allele carriers during CHD groups and control groups(χ2=1.40,P=0.23). Conclusions GLI1 gene rs10783826 polymorphism is not associated with CHD.The allele is not affect CHD in newborn.
Key words
glioma associated oncogene homolog1 /
polymorphism /
congenital heart disease /
newborn
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