Objectives To observe the changes of the expression of calcium-sensing receptor and Pi3k/Akt pathway in regulating cardiac myocyte apoptosis of epilepsy rat. Methods Adult male Wistar rats were divided into two groups randomly:normal control group and epilepsy group.The epilepsy rats group model were induced by subcutaneous injection of PTZ (64 mg/kg once).The level of CK,CK-MB and cTnI were assayed by ultraviolet spectrophotometry.The morphological changes of cardiac tissues were observed under optical and electron microscopy.Heart rate and the cardiac function of the rats in each group were detected by echocardiography.The expressions of CaSR,Akt and p-Akt were analyzed by western blot. Results Compared with control group,CK,CK-MB and cTnI were increased obviously in epilepsy group (P<0.05).HE staining showed the cell swelled,and the nuclear fragmented.EEG showed epilepsy waves.By echocardiography,rhythm of the heart was increased,the left ventricular wall motion was abnormal,and the rhythm was disorder.The expression of CaSR,p-Akt were increased in epilepsy group(P<0.05),while Akt had no difference between of them. Conclusion Epileptic may injured cardiac tissues,and induced the increased expression of CaSR,and actived Pi3k/Akt pathway,then increased the expression of p-Akt,all of them regulated the cardiac myocyte apoptosis.