Correlation study of estrogen receptor 1 (ESR1) gene polymorphism and premature infants intraventricular hemorrhage.

PAN Jin-yong; ZHANG Hui-rong; CAO Xiao-yan; DUAN Wei-hao.

doi:10.11852/zgetbjzz2016-24-05-05

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Chinese Journal of Child Health Care ›› 2016, Vol. 24 ›› Issue (5) : 462-465. DOI: 10.11852/zgetbjzz2016-24-05-05

Correlation study of estrogen receptor 1 (ESR1) gene polymorphism and premature infants intraventricular hemorrhage.

PAN Jin-yong,ZHANG Hui-rong,CAO Xiao-yan,DUAN Wei-hao.

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Abstract

Objective To detect the polymorphism of estrogen receptor 1 (estrogen receptor alpha,ESR1),to analyze the relationship of ESR1 genotypes and intraventricular hemorrhage (IVH),to understand the pathogenesis and influence factors of intraventricular hemorrhage on premature infant,and to further improve the prevention,diagnosis,treatment and prognosis. Methods The diagnosis of 45 newborns of intraventricular hemorrhage were confirmed by head CT examination from January 2012 to February 2015,50 cases of normal newborn were selected as the control group.Using endonuclease PvuII in the disease samples and normal samples for ESR1 gene polymorphism,and the distribution and correlation of ESR1 gene polymorphism with premature infant intraventricular hemorrhage were analyzed. Results Premature infant's intraventricular hemorrhage with PvuII restriction fragment length polymorphism showed polymorphism,rs2234693 genotype was genotype CC (213 bp),the TT genotype (179/34 bp) and CT genotype (213/179/34 bp).In IVH experimental group,ESR1 (rs2234693) TC type and the frequency loci were higher than those of the control group,the difference was statistically significant between the two groups (χ²=6.57,P<0.05).The experimental group's IVH ESR1 (rs2234693) of TC allele frequency was higher than that of the control group,the difference was statistically significant between the two groups (χ²=5.40,P<0.05). Conclusion There is a correlation between the ESR1 gene rs2234693 locus T and the premature infant intraventricular hemorrhage.

Key words

intraventricular haemorrhage in premature infants / gene polymorphism / estrogen receptor alpha gene

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PAN Jin-yong,ZHANG Hui-rong,CAO Xiao-yan,DUAN Wei-hao.. Correlation study of estrogen receptor 1 (ESR1) gene polymorphism and premature infants intraventricular hemorrhage.[J]. Chinese Journal of Child Health Care. 2016, 24(5): 462-465 https://doi.org/10.11852/zgetbjzz2016-24-05-05

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