Objective To investigate impact of the core symptoms of autism spectrum disorders(ASD) on healthrelated quality of life（HRQoL） in children. Methods The children with ASD who participated in structured training class in April to October,2014 in the Children's Hospital of Chongqing Medical University were researched.Core symptoms questionnaire and the Scale of Life Quality( PedsQLTM 4.0)，were used to analyze the relationship between the core symptoms and the HRQoL of ASD. 〓〖WT5"HZ〗Results〖WT5"BZ〗〓1) The relationships of patterns of restricted or repetitive interests and behaviors with PedsQL total score,emotional function,social function were negatively correlated （r=-0.503，-0.600，-0.474）,there were statistically significant （P<0.01），no significant correlation was found with physiological function,school performance.There was no significant correlation in social barriers associated with HRQoL of children with ASD.2)In mild patterns of restricted or repetitive interests and behaviors of children with ASD，the PedsQL total score,physical function,emotional function,social function and school function were higher than severe patterns of restricted or repetitive interests and behaviors of children with ASD,differences in emotional function,social function were statistically significant（P<0.05）.Overall quality of life,physical function,school performance differences were not statistically significant. Conclusions 1)The children with ASD is poor HRQoL.HRQoL relate to patterns of restricted or repetitive interests and behaviors.2)The more serious of patterns of restricted or repetitive interests and behaviors of children with ASD,the more worse HRQoL of children with ASD had.Improving patterns of repetitive interests and behaviors of children with ASD is will help improve HRQoL of children with ASD.