Objective To analyse the cognitive development of 4 year old children conceived by intracytoplasmic sperm injection (ICSI). Methods Children enrolled into our study were conceived by ICSI from January 2009,through to the end of December 2009 in the State key Laboratory of Reproductive Medicine Department of Nanjing Maternal and Child Health Care Hospital.18 ICSI alive single born underwent cognitive assessments and 36 spontaneously conceived (SC) singletons as control subjects were matched with respect to age,gender,and birth number.The children were excluded if their gestational weeks less than 32 weeks,birth weight less than 1 500 g,with fetal distress or birth asphyxia history.Children's cognitive development was assessed with the Chinese-Wechsler preschool and primary scale of intelligence (C-WPPSI). Results Singletons conceived by ICSI achieved lower IQ scores than SC singletons (full-scale IQ:ICSI 100.67±11.45,SC 115.33±10.82; verbal IQ:97.72±14.21,111.72±12.40;performance IQ:104.83±7.87,SC 116.50±10.68,P<0.05).However,ICSI children obtained lower scores on the "picture completion" subtests (ICSI 4/18,SC 0/36,χ2=8.64,P<0.05). Conclusion In the relatively limited sample investigated,cognitive development among ICSI singletons is lower than SC singletons.By refining assessment content,expanding the sample size and extending follow-up time,we can provide more powerful evidence for judgment of the long-term developmental outcomes of assisted reproductive offspring.
Key words
assisted reproductive technology /
intracytoplasmic sperm injection /
offspring /
cognitive
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