Objective To explove the influence of Hepatitis B vaccine (HBV) event on children's immunization,assess the extent and lasting time. Method The data of vaccines use of children's routine immunization were collected from 2011 to 2014 and focused on data from 2013 to 2014. Results The usage of first type vaccines in 2014 was decreased 8.57% compared to 2013,the lowest month was January 2014,first type vaccines and free HBV vaccine felled 43.24% and 50.38% compared with the same period in 2013.After HBV vaccine event,usage of the second type vaccine was increased steadily,rose 8.64% compared with 2013.The substitute ratio of first type vaccine was 39.38% in 2014,rose 11.57% compared with 2013. Conclusion The HBV event had caused a great impact on first type vaccine immunization,the wishes of parents to choose second type vaccine increased,we should enhance propaganda on efficacy and safety of first type vaccine,restore parents' vaccination confidence.