Meta-analysis of risk factors related to the induction of embryo damage

GUO Li-yan; ZHAI Min; WANG Sha-sha; ZHANG Yan

doi:10.11852/zgetbjzz2016-24-02-16

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Chinese Journal of Child Health Care ›› 2016, Vol. 24 ›› Issue (2) : 166-179. DOI: 10.11852/zgetbjzz2016-24-02-16

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Meta-analysis of risk factors related to the induction of embryo damage

GUO Li-yan,ZHAI Min,WANG Sha-sha,ZHANG Yan

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Abstract

Objective To investigate the risk factors related to the induction of embryo damage with meta-analysis and to provide theoretic evidence for the exploration and prevention. Methods References related to embryo damage were retrieved and collected with case-control study.Mantel-Haensel fixed effect model and Dersimonian-Laird random effect model were used to perform meta-analysis by Review Manager 5.2. Results Thirty-seven articles which included 7 223 cases in embryo damage group and 6 689 cases in control group were synthetically and quantitatively analyzed by Meta-analysis.The factors with odds ratios and 95% confidence intervals in descending order were Chlamydia trachomatis 8.46(5.84~12.25),Mycoplasma urealytium 6.13(4.45~8.43),Chlamydia trachomatis and mycoplasma urealytium 5.90(3.7 7~9.25),radiation 4.83(3.63~6.44),smoking passively 4.27(3.76~4.85),home decoration 2.11(1.76~2.54),pregnancy anxiety 1.42 (1.25~1.59);pre-marital check-up 0.60(0.51~0.71),physical exercise 0.45(0.35~0.57).All these factors were statistically significant. Conclusion Chlamydia trachomatis,Mycoplasma urealytium,radiation and smoking passively were considered to be risk factors of embryo damage,while pre-marital check-up and physical exercise might be associated with protective factors.

Key words

embryo damage / missed abortion / risk factors / Meta-analysis

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GUO Li-yan,ZHAI Min,WANG Sha-sha,ZHANG Yan. Meta-analysis of risk factors related to the induction of embryo damage[J]. Chinese Journal of Child Health Care. 2016, 24(2): 166-179 https://doi.org/10.11852/zgetbjzz2016-24-02-16

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