Objective To investigate the effects of high zinc intake in early life on insulin levels in adulthood with high fat diet. Methods Totally 85 male SD weanling rats were randomly divided into basic diet group,high zinc group,medium zinc group and low zinc group.After 4 weeks,all rats were fed with basic diet for 1 week,then Fasting plasma glucose and fasting plasma insulin were detected,and the insulin sensitively index were calculated.The basic diet group then were randomly divided into obesity induction group and normal control group.Three zinc supplementation groups and obesity induction group were fed with high fat diet for 8 weeks.All rats were then put to death,the above indicators were detected and calculated. Results After high fat intervention,1)the body weight of three zinc supplementation groups were significantly lower than that of obesity induction group (P＜0.05);2) fasting plasma glucose and fasting plasma insulin of three zinc supplementation groups were significantly lower than those of obesity induction group (P＜0.05),and the insulin sensitively index was significantly higher (P＜0.05). Conclusion Appropriate zinc supplement in early life can play a continuous function,it can maintain the fasting plasma glucose and fasting insulin at normal levels to a certain extent after adulthood with high fat diet and prevent insulin resistance.
Key words
weanling rat /
zinc supplementation /
high-fat intervention /
insulin resistance
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References
[1] YV Li.Zinc and insulin in pancreatic beta-cells [J].Endocrine,2014,45(2):178-189.
[2] Christian P,Stewart CP.Maternal micronutrient deficiency,fetal development,and the risk of chronic disease[J].J NUTR,2010,140(3):437-445.
[3] 朱莲珍.人和动物的微量元素营养[M].青岛:青岛出版社,1994:480-481.
[4] Barker DJ,Martyn CN.The maternal and fetal origins of cardiovascular disease[J].Journal of Epidemiology and Community Health,1992,46(1):8-11.
[5] Ramune J,Bo A,Marta B,et al.The influence of early exposure to vitamin D for development of diseases later in life[J].BMC Public Health,2013,13:2-8.
[6] 徐姝迪,张克远,王忠.高钙饲料喂养初断乳大鼠对成年期高脂形成肥胖的影响[J].营养学报,2013,58(2):154-157.
[7] 朱洋,姜信曾,张云磊.断乳后不同剂量铁强化膳食对大鼠成年期肥胖诱导后瘦素水平的影响[J].中国妇幼保健,2015,30(2):284-286.
[8] Biddinger SB,Kahn CR.From mice to men:insights into the insulin resistance syndromes [J].Annual Review of Physiology,2006,68:123-158.
[9] 王冠怡,许岚,蒋艳敏,等.无锡地区50岁以上居民肥胖及相关指标与胰岛素抵抗的关系[J].中华内分泌代谢杂志,2014,30(6):495-498.
[10] 宋文琪,李时莲,张美和,等.儿童肥胖持续时间与血锌、血糖及胰岛素含量关系的探讨[J].中华检验医学杂志,2011,34(5):419-421.
[11] 张岩,陈晓亭,宋惠珠,等.肥胖所导致的胰岛素抵抗分子机制的研究进展[J].检验医学,2014,29(7):774-778.
[12] 刘信艳,吴蕴棠,孙忠,等.锌对高糖高脂饲料喂养大鼠胰岛素敏感性影响[J].中国公共卫生,2013,29(5):691-693.
[13] Robertson RP,Zhou H,Slucca M.A role for zinc in pancreatic islet β-cell cross-talk with the α-cell during hypoglycaemia[J].Diabetes,Obesity and Metabolism,2011,13(1):106-111.
[14] 赵艾,薛勇,陈云,等.学龄前儿童锌摄入情况及其对生长发育的影响[J].中国儿童保健杂志,2015,23(2):169-172.
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