Polymorphism of vitamin D receptor gene Bsm I and Fok I of the Han nationality children in Shenzhen city.

WANG Yue-juan; LU Yan-qiang; LI Hui-juan; LI Ying; ZHU Ping; CHEN Chun-bao.

doi:10.11852/zgetbjzz2016-24-01-06

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Chinese Journal of Child Health Care ›› 2016, Vol. 24 ›› Issue (1) : 19-21. DOI: 10.11852/zgetbjzz2016-24-01-06

Polymorphism of vitamin D receptor gene Bsm I and Fok I of the Han nationality children in Shenzhen city.

WANG Yue-juan¹,LU Yan-qiang²,LI Hui-juan¹,LI Ying²,ZHU Ping²,CHEN Chun-bao³.

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Abstract

Objective To explore the polymorphism distribution of vitamin D receptor(VDR)gene Bsm I and Fok I in Han nationality children in Shenzhen,improve the compliance of children's scientific calcium and promote children's growth and development. Methods A total of 233 Han nationality children were recruited and collected oral epithelial cells.Genome DNA for fluorescence quantitative PCR to detect SNPs of Bsm I and Fok I were extracted.The Results were compared with the distribution frequencies of Bsm I and Fok I in other regions. Results The frequencies of Bsm I ( bb,Bb,BB ) in Han nationality children were 88.4%,11.6%,0 in Shenzhen,respectively.The frequency of Fok I ( ff,Ff,FF ) in Han nationality children were 18.6%,52.0%,29.4% in Shenzhen respectively. Conclusion Bsm I and Fok I polymorphism distribution in Han nationality children of Shenzhen city exhibit the own characteristics.

Key words

vitamin D receptor / gene polymorphism / Han nationality

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WANG Yue-juan,LU Yan-qiang,LI Hui-juan,LI Ying,ZHU Ping,CHEN Chun-bao.. Polymorphism of vitamin D receptor gene Bsm I and Fok I of the Han nationality children in Shenzhen city.[J]. Chinese Journal of Child Health Care. 2016, 24(1): 19-21 https://doi.org/10.11852/zgetbjzz2016-24-01-06

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