Clinical study of passive smoking pregnant maternal plasma interleukin-6 and interleukin -10 and preterm.

CHENG Gui-hui; CUI Qi-liang; QIU Qi-zhou; XIONG Wei; YANG Yong-ling; XIAO Yi

doi:10.11852/zgetbjzz2015-23-11-17

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Chinese Journal of Child Health Care ›› 2015, Vol. 23 ›› Issue (11) : 1175-1177. DOI: 10.11852/zgetbjzz2015-23-11-17

Clinical study of passive smoking pregnant maternal plasma interleukin-6 and interleukin -10 and preterm.

CHENG Gui-hui¹,CUI Qi-liang²,QIU Qi-zhou¹,XIONG Wei¹,YANG Yong-ling¹,XIAO Yi¹

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Abstract

Objective To study pregnancy changes of plasma interleukin-6 (IL-6) and interleukin-10 (IL-10) in the passive smoking pregnant women to explore it's relationship with premature. Methods According to the exist of passive smoking,155 cases of premature pregnant (28~36⁺⁶ weeks) of study group were divided into two groups,study group 1 as passive smoking group,study group 2 during pregnancy without passive smoking or smoking; and 82 cases of pregnant women were selected as the control group (no passive smoking or smoking during pregnancy and the final normal term labor).Maternal plasma IL-6 and IL-10 concentrations were tested by enzyme-linked immunosorbent assay during 28~36⁺⁶ weeks' gestation. Results Maternal plasma IL-6 concentration of study group 1 were significantly higher than that of study group 2 and control group(P<0.05);But maternal plasma IL-10 concentration of study group 1 was lower than that of the study group 2,but had no significant difference(P>0.05);and maternal plasma IL-10 concentration of study group was significantly lower than that of control group(P<0.05). Conclusion Passive smoking during pregnancy can cause IL-6 increased significantly,and IL-10 decreased,which may participate in the mechanism of passive smoking causing premature high-risk,to increase the risk of preterm delivery.

Key words

passive smoking / interleukin-6 / interleukin-10 / premature

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CHENG Gui-hui,CUI Qi-liang,QIU Qi-zhou,XIONG Wei,YANG Yong-ling,XIAO Yi. Clinical study of passive smoking pregnant maternal plasma interleukin-6 and interleukin -10 and preterm.[J]. Chinese Journal of Child Health Care. 2015, 23(11): 1175-1177 https://doi.org/10.11852/zgetbjzz2015-23-11-17

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