Objective To study the effect of conductive education combined with auditory integration training on mental retardation (MR) in preschool children. Methods A total of 61 preschool children with MR were randomly divided into two groups.In control group,the children were assigned to receive family training at home,such as sensory integration,living skills and social adaptation ability training.In treatment group,the children received family training and a comprehensive rehabilitation treatment of conductive education combine with auditory integration.Curative effects were compared with after six months treatment between treatment group and control group. Results The total efficiency was 96.77% in treatment group and 70.00% in control group.After the intervention,the intelligence quotient (IQ) in treatment group was significantly higher than that in control group(P<0.05).And the IQ difference before and after intervention in treatment group was significantly higher than that in control group(P<0.05). Conclusion Conductive education combine with auditory can improve the intellectual development and elevation more significantly in preschool children with mental retardation than only received family training at home.