Objective To study the infection state of virus in hospitalized children suffered with acute respiratory infection (ARI) in Cangzhou district from May 2012 to July 2013. Methods The 7 common respiratory viruses,including respiratory syncitial virus (RSV),adenovirus (ADV),influnenza (IFV) A and B,and parainfluenza (PIV 1,2,3),were detected using direct immunofluorescence viral antigen rapid diagnosis in nasopharyngeal aspirate (NPS) of children with ARI. Results In totally 741 samples,28.6% ( 212/741) was shown to be viral positive.There were no significant differences in the infection rates between genders(P=0.753).Among the seven kinds of virus,the highest infection rate was 16.1% of RSV,followed was 4.5% of PIV3.The highest total infection rate was 45.0% in winter,and the lowest total infection rate was 15% in autumn.The infection rate in ≤3-year-old children group was significantly higher than that of ≥3-year-old children group(P<0.01). Conclusions RSV is the most common viral pathogen in children hospitalized with ARI in Cangzhou.The epidemic of respiratory viruses could be with obvious seasonal characteristics,and the highest rate of respiratory virus infection might be in winter and spring.The infection rate of different virus could be different in children at different age.