Objective To discuss the changes of learning and memory ability of fetal rats with fetal growth restriction(FGR) with maternal zinc supplementation. Methods FGR model of SD rats was constructed according to the method of passive smoking.The pregnant rats were divided into three groups (the FGR group contained 10 rats,the model group contained 10 and the control group contained 11 rats).The model group was fed with supplementation of zinc,and the other two groups were fed on normal food.Within each group,10 pups were randomly selected into three subgroups to be tested at 1,2 and 4 months of age,respectively(only FGR pups were selected in the FGR and the model group).Morris water maze task was performed to assess the spatial learning and memory abilities of the rats. Results At the age of 1,2 and 4 months,the fetal rats in the model groups were more likely to use effective strategies to find the platform than the FGR group(P<0.05),and were similar with the control group(P>0.05).The escape latencies to find the platform were shortened with increased training times for all of the rats (P<0.05).At the age of 1,2 and 4 months,the escape latencies of the fetal rats in the model group were more increased than the latency times of the control group(P<0.05).Except the age of 4 months,the latency times of the fetal rats in the model group were decreased than the FGR group (P<0.05),and also stayed in the platform more than the FGR group (P<0.05).While at the age of 4 months,the times spent staying in the platform of the model group and FGR group had no significance (P>0.05). Conclusions Maternal zinc supplementation could improve the scores of the FGR fetal rats in Morris water maze,so that showed us to add zinc in pregnant time could protect the impaired of the learning and memory abilities caused by FGR.Postnatal behavior training could correct the impairment of the brain caused by FGR.
Key words
fetal growth restriction /
zinc /
learning and memory /
Morris Water Maze
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