Objective To explore the effects of grandparenting on infants' physical and psychological growth,in order to put forward the reasonable suggestions for improving the quality of infants. Method Data of 1∶1 paired of 136 cases of grandparents-raised children and parents-raised children was analyzed between 12 months old and 24 months old. Results There was no significant difference at physical growth indicators between the groups of grandparents-raised children and parents-raised children.At the age of 12 months,language score of the group raised by grandparents was lower than it raised by parents (P<0.05).At the age of 24 months,the developmental quotient of the group raised by grandparents were lower than it raised by parents (P<0.05). Conclusions Grandparenting is not good for children's early psychological and physical growth.Parents and grandparents should strengthen communication,complementary advantages,in order to promote the healthy growth of children.