Objective To explore first aid knowledge skills training model that suitable for middle school students through the baseline investigation and analysis of Yinchuan area middle school students to master degree of first aid knowledge skills. Methods By designed questionnaire,2 112 middle school students' first aid knowledge were tested before training,and then the training effect with the same questionnaire were tested after training.With "participatory teaching method",the middle school students learned first aid knowledge and skills in emergency scenario design,skills operation,and interactions between schoolmates.The first aid skills operation training effect was tested before and after training.Among 2 112 students,300 students of 12 years old,13 years old,14 years old were randomly selected,related data were collected for statistics and analysis,the training effect was evaluated . Results Qualified rate of different gender,age,area before and after training had statistically significant difference (P<0.05);In trauma,dog bites,cardiopulmonary resuscitation (CPR),burns,drowning,airway foreign bodies blocked,the six knowledge awareness of training in gender,age,region had significant difference (P<0.05) before and after training.76.84% of the students liked "game" training form,70.52% liked "work in practice operation" training form ,and 63.19% liked "role play" training form. Conclusion The participatory teaching method to the first aid knowledge and skills training in the middle school students have obvious effects,the method is effective and worth popularizing in the whole country.