Objective Through Neonatal Health Care Platform based on WeChat Public Platform to evaluate the effort of this platform in neonatal health care. Methods To choose early pregnant women who were need pregnancy test,they were divided into subscription group and non-subscription group according to whether subscribe the neonatal health care platform based on WeChat public platform.Using the platform to disseminating neonatal health care knowledge for subscription group to observe and assess the newborns of the two groups. Results In comparison of subscription and non- subscription group,there were significant differences in acceptances of phenylketonuria screening,thyroid hypofunction screening,hearing screening and neonatal behavior neurological assessment;The subscription group was better than non-subscription group in the conditions of weight growth of newborns after birth 28 days and pure maternal breast-feeding;In mastering situation on neonatal care knowledge,the subscription group was better than non-subscription group;The subscription group had lower morbidity rates than non-subscription group in some diseases. Conclusion To spread on neonatal health care knowledge by establishment of neonatal health care platform based on WeChat public Platform can achieve the promotion the healthy growth of newborns and prevention of disease.