Object To analyze the age distribution,death time,cause of death,hospital mortality of hospitalized children death cases in Wuhan Children's Hospital during nearly twelve years,and try to point out the variation trend. Methods A retrospective statistical analysis was used on 1 179 hospitalized children death cases from 2003 to 2014 in Wuhan Children's Hospital. Results The total mortality among hospitalized children was 0.19% from 2003 to 2014.In previous 10 years,the alteration of mortality rate in each year had no significance.From the beginning of 2013,the trend of mortality rate was decreased.The majority death age of hospitalized children death case was neonatal,accounted for 39.02%.The second was 1 year old infants,accounted for 31.98%.And most of the time of death was within 9 days after admission.In accordance with the system to classification,the top five causes of death were neonatal disease,respiratory diseases,congenital malformations,nervous system diseases and digestive diseases,respectively.The top five diseases of death were pneumonia,congenital heart disease,central nervous system infections,sepsis and neonatal pneumonia,respectively. Conclusions The focal point of reducing hospitalized children death is improving the level of diagnosis and treatment of dangerous diseases,such as neonatal disease,infectious diseases and congenital malformation.