objective To explore the risk factors of parenteral nutrition-associated cholestasis (PNAC) in extremely low birth weight infants(ELBWI). Methods The clinical data of 229 ELBWI receiving parenteral nutrition (PN) for more than two weeks in neonatal intensive care unit (NICU) were retrospectively analyzed.The differences between PNAC group and non-PNAC group about gestational age,birth weight,sex,et al were compared. Results The incidence of PNAC was 11.79%(27/229).Compared with non-PNAC group,the average gestational age and birth weight in PNAC group were lower; Average PN duration,average energy intake,the large fat milk dosage and accumulative dosage were higher;The incidence of infection and anemia in PNAC group were higher too(P<0.05). Conclusion The incidence of PNAC is associated with lower gestational age,lower birth weight,longer PN duration,higher energy intake,larger fat milk dosage and accumulative dosage,infection and anemia.
Key words
extremely low birth weight infants /
parenteral nutrition /
cholestasis
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