Objective To analyze influencing factors of adsorbed acellular DPT combined vaccine (DTaP) adverse events following immunization (AEFI) and improve the AEFI management.Methods From January 2011 to December 2014 in Navigation Road community health service center of our hospital,41 cases with DTaP AEFI reaction were retrospectively monitoring analyzed.Results During the period of DTaP inoculation,28 494 children aged from three months to 2 years were vaccinated,41 children appeared AEFI reaction,the incidence rate was 0.144%.Compared through 4 years,the AEFI reaction rate showed a downward trend in overall (χ2=8.614,P=0.035).Conclusions Data showed,AEFI appeared in each month throughout the year.AEFI reaction rates were higher in the month of August and July,with a high trend in summer,and often occurred in the third or fourth pin.The AEFI of DTaP vaccine was related with inherent characteristics,children's age,inoculation time,inoculation time,seasonal vaccination and other related technology.Strictly standardized safety operation,close attention to the vaccination contraindication and the high incidence time of AEFI,completing the vaccination information warning,could reduce the AEFI.