Objective To compare qualitative general movements assessment (GMs assessment) and 20 items neurological assessment from birth to 1 year (20 items assessment) for gross motor outcome and cerebral palsy in high risk infants.Methods According to the inclusion criteria,30 infants were confirmed as the participants.GMs and 20 items were assessed one times during fidgety movements period (correct age from 9 weeks to 5 months).Gross motor outcome and cerebral palsy were determined by clinic performs and Peabody Developmental Motor Scale at least after one year old.Sensitivity,specificity,positive predictive value,negative predictive value and Kappa index were calculated.Results 3（10%） infants were cerebral palsy,5 (16.7%) infants were gross motor retardation,25(83.3%) infants were normal gross motor development.Predictive validity of GMs for gross motor retardation was as follows：sensitivity 80.0%,specificity 96.0%,positive predictive value 80.0%,negative predictive value 96.0%；Predictive validity of 20 Items for gross motor retardation was as follows：sensitivity 100.0%,specificity 92.6%,positive predictive value 60.0%,negative predictive value 100.0%；Predictive validity of GMs for cerebral palsy was as follows：sensitivity 100.0%,specificity 92.6%,positive predictive value 60.0%,negative predictive value 100.0%；Predictive validity of 20 Items for cerebral palsy was as follows：sensitivity 100.0%,specificity 85.2%,positive predictive value 42.9%,negative predictive value 100.0%；Kappa=0.59.Conclusions During fidgety movements period，predictive validity for gross motor retardation of two methods have advantages,GMs is better at predicting cerebral palsy.Two methods with moderate consistency,have comprehensive application in high risk infants follow-up work.