Objective To review the glucose-6-phosphate dehydrogenase (G6PD) deficiency in cases of neonatal hyperbilirubinemia(NHB) to prevent hyperbilirubinemia in early neonatal stage and hemolysis in lifelong. Methods The activity of G6PD was detected by the method of quantitative G6PD/6-phosphaogluconate dehydrogenase (6PGD) ratio and the clinical features of total bilirubin(TB),unconjugated bilirubin(UCB),red blood cell count (RBC),hemoglobin(Hb) level were reviewed. Results A total of 24 cases(23 male infants and 1 female infants) of G6PD deficiency were detected among the 1 792 newborns with hyperbilirubinemia.The serum TB was (34.3±177.6)μmol/L,mean RBC and Hb levels were (3.51±0.88)×1012 /L and (121±27)g/L respectively.There was no significant correlation between TB and G6PD/6PGD ration,RBC,or Hb. Conclusions For the causes to NHB,G6PD deficiency is characterized by early onset,rapid progression levels of G6PD,RBC,Hb can not reflect the severity of jaundice.G6PD screening for neonatal hyperbilirubinemia is necessary to execute as soon as possible.
Key words
hyperbilirubinemia /
glucose-6-phosphate dehydrogenase deficiency /
newborn /
screening
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