Objective To investigate the effects of early nutritional status of very low birth weight infants (VLBWI) in neonatal intensive care unit (NICU) on their neurologic development thereafter.Methods The study was conducted in NICU of Guangzhou Women and Children's Medical Center from January 2013 to June 2014.A total of 86 VLBWIs who met the entry criteria had been followed up in highrisk infant outpatient service after leaving hospital regularly,and they were assigned to two groups (normal neural development group and abnormal neurologic development group) according to their development quotients (DQ) examined through development test at 3 months corrected age,then their nutritional status were analyzed during hospitalization respectively.Results In normal neurologic development group,the gross energy and the proportion of enteral energy were higher compared with abnormal neurologic development group on 4 d,7 d and 14 d after birth,and the supply of amino acids was also higher than that abnormal neurologic development group on 4 d and 7 d after birth,the statistical differences were significant (P<0.05);Compared with abnormal neurologic development group,the weight reduction of VLBWIs in normal neurologic development group was less and they could revert to birth weight and achieve full gastrointestinal feeding earlier,the difference between two groups had statistical significance (P<0.05).Conclusion Early better nutritional status of VLBWI can improve the effects of their neurologic development significantly.
Key words
nutritional status /
neurologic development /
very low birth weight infants
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 曹云.营养与早产儿神经发育结局[J].临床儿科杂志,2012,30(3):208-211.
[2] Nash A,Dunn M,Asztalos E,et al.Pattern of growth of very low birth weight preterm infants,assessed using the WHO Growth Standards,is associated with neurodevelopment[J].Appl Physiol Nutr Metab,2011,36(4):562-569.
[3] 宋燕燕,赖剑蒲.围生期高危儿监护管理学[M].北京:人民军医出版社,2012:354-355.
[4] Lind A,Parkkola R,Lehtonen L,et al.Associations between regional brain volumes at term-equivalent age and development at 2 years of age in preterm children[J].Pediatr Radiol,2011,41(8):953-961.
[5] Hay WW Jr.Aggressive nutrition of the preterm infant[J].Curr Pediatr Rep,2013,1(4):229-239.
[6] Ziegler EE,Thureen PJ,Carlson SJ,et al.Aggressive nutrition of the very low birth weight infant[J].Clin Perintol,2002,29(2):225-244.
[7] Franz AR,Pohlandt F,Bode H,et al.Intrauterine,early neonatal,and postdischarge growth and neurodevelopmental outcome at 5.4 years in extremely preterm infants after intensive neonatal nutritional support[J].Pediatrics,2009,123(1):101-109.
[8] Tan MJ,Cooke RW.Improving head growth in very preterm infants-a randomised controlled trial I:neonatal outcomes[J].Arch Dis Child Fetal Neonatal Ed,2008,93(5):F337-F341.
[9] Stephens BE,Walden RV,Gargus RA,et al.First-week protein and energy intakes are ssociated with 18-month developmental outcomes in extremely low birth weight infants[J].Pediatrics,2009,123(5):1337-1343.