Objective To learn the effect of diet intervention on prevention of allergic disease in high risk infants.Methods A total of 200 high risk infants were recruited and randomly divided into intervention group(diet control) and non-intervention group.A randomly controlled trial was conducted to compare the development of allergic diseases between two groups for 12 months. Results 1) After 6 months and 12 months follow up,the incidences of eczema and asthma in the intervention group were significantly lower than those in the non-intervention group (P<0.05).After 12 months,the incidence of allergic rhinitis in the intervention group was significantly lower than that in the non-intervention group (P<0.05).After the 12 months intervention,the severity of eczema,asthma and allergic rhinitis decreased significantly (P<0.05).2) There were significant differences in allergen detection Results and food allergen detection Results between intervention group and non-intervention group after 6 months and 12 months (P<0.05).After 12 months,the TPTEF/TF and VPEF/VE in the intervention group was significantly higher than that in the non-intervention group (P<0.05).Conclusion Early diet intervention can reduce the incidence of allergic diseases and alleviate the development of allergic diseases in high risk infants.
Key words
high risk infants /
moderately hydrolyzed whey potein formula /
allergy prevention /
food allergy
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References
[1] Spergel JM.Atopic march:link to upper airways[J].Curr Opin Alergy Clin Immunol,2005,5(1):17-21.
[2] Sicherer SH,Burks AW.Maternal and infant diets for prevention of allergic disease:understanding menu changes in 2008[J].J Allergy Clin Immunol,2008,122:29-36.
[3] Fleischer DM,Spergel JM,Assa'ad AH,et al.Primary prevention of allergic disease through nutritional interventions[J].J Allergy Clin Immunol:In Practice,2013,1:29-37.
[4] Oranje AP,Glazenburg EJ,Wolkerstorfer A,et al.Practical issues on interpretation of scoring atopic dermatitis:the SCORAD index,Objective SCORAD and the three-item severity score[J].British Journal of Dermatology,2007,157(4):645-648.
[5] 中华医学会儿科学分会呼吸学组,中华儿科杂志编辑委员会.儿童支气管哮喘诊断与防治指南(2008年修订)[J].中华儿科杂志,2008,46(10):745-753.
[6] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组、小儿学组,中华儿科杂志编辑委员会.儿童变应性鼻炎诊断和治疗的专家共识[J].中华儿科杂志,2011,49(2):116-117.
[7] 闫俊梅,陈静,黎海芪.婴幼儿鸡蛋与牛奶过敏食物皮肤点刺试验的诊断价值[J].中华儿科杂志,2011,49(5):329-332.
[8] 邵洁,夏振炜,李云珠.IgE介导的食物过敏诊断程序及临床评价[J].临床儿科杂志,2007,25(1):23-25.
[9] 张皓,邬宇芬,黄剑峰.儿童肺功能检测及评估专家共识[J].临床儿科杂志,2014,32(2):104-113.
[10] 邵洁.儿童过敏性疾病的早期预防[J].临床儿科杂志,2012,30(4):398-400.
[11] Rhodes HL,Thomas P,Sporik R,et al.A birth cohort study of subjects at risk of atopy:twenty-two-year follow-up of wheeze and atopic status[J].Am J Respir Crit Care Med,2002,15,165(2):176-180.
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