Relationship between growth hormone receptor gene polymorphism and idiopathic short stature in Guangxi Yao nationality children.

ZENG Ting; YAN Ti-zhen; TANG Ning; LI Hong-hui; LI Wu-gao; LI Zhe-tao; ZHANG Yu.

doi:10.11852/zgetbjzz2015-23-07-08

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Chinese Journal of Child Health Care ›› 2015, Vol. 23 ›› Issue (7) : 699-702. DOI: 10.11852/zgetbjzz2015-23-07-08

Relationship between growth hormone receptor gene polymorphism and idiopathic short stature in Guangxi Yao nationality children.

ZENG Ting¹,YAN Ti-zhen²,TANG Ning²,LI Hong-hui¹,LI Wu-gao²,LI Zhe-tao²,ZHANG Yu¹.

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Abstract

Objective To investigate the relationship between growth hormone receptor (GHR) gene single nucleotide polymorphism (SNP) and idiopathic short stature (ISS) in Guangxi Yao nationality children.Methods A total of 100 ISS children and 100 normal control children were recruited.Height,body mass index (BMI) and serum insulin-like growth factor-1 (IGF-1) level were measured.Genomic DNA was extracted from the peripheral blood leukocytes,and the GHR gene rs4410646,rs2940913,and rs12515480 polymorphisms were genotyped by SNaPshot method. Results The genotype frequencies of rs4410646 (A/C) in ISS children were significantly different from those in controls (P<0.05).The allelic frequencies of rs4410646 in ISS children were not significantly different from those in controls (P>0.05).The genotype and allelic frequencies of rs2940913 (A/C) and rs12515480 (C/T) in ISS children were not significantly different from those in controls (P>0.05).The IGF-1 level within the ISS group was significantly lower than that of the control group (P<0.05).Conclusion GHR gene rs4410646,rs2940913,and rs12515480 polymorphisms are not associated with idiopathic short stature in Yao nationality children of Guangxi province.

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idiopathic short stature / growth hormone receptor gene / Yao nationality

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ZENG Ting,YAN Ti-zhen,TANG Ning,LI Hong-hui,LI Wu-gao,LI Zhe-tao,ZHANG Yu.. Relationship between growth hormone receptor gene polymorphism and idiopathic short stature in Guangxi Yao nationality children.[J]. Chinese Journal of Child Health Care. 2015, 23(7): 699-702 https://doi.org/10.11852/zgetbjzz2015-23-07-08

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