Objective To provide a reference for public health policy of preventing children from lead poisoning by detecting the lead concentrations in peripheral blood of 2 285 preschoolers in Daliang,Shunde. Methods The lead in peripheral blood of 2 285 preschoolers was determined by inductively coupled plasma-mass spectrometry (ICP-MS).The results were analyzed. Results The average blood lead level in these 2 285 cases was (44.77±17.73)μg/L,the rate of lead intoxication was 1.8%.The most cases had low-grade lead intoxication.The rates of lead intoxication in different sex and different district showed significant differences (P＜0.05).The rate of boys' lead poisoning was significantly higher than girls' (P＜0.05).The rate of village children's lead poisoning was significantly higher than town children's (P＜0.01). Conclusion Within the industrial production process,we need to pay attention to the proper setup and the prevention of lead intoxication under children in village areas; strengthening ecological awareness among inhabitants,cutting back the use of leaded fuel and materials containing lead;incorporate gradually free for blood lead testing in basic children healthcare and periodic checkup programs in kindergarten,to ensure that children can grow up safely.