Objective To study the effects of different nutrition on preterm children's weight (extrauterine growth retardation, EUGR) and gastrointestinal hormone. Methods Using the Methods of control study clinical, a total of 106 premature children who stay in Baoji Second People's hospital NICU from January 2011 to December 2014, were selected and randomly divided into observation group and control group, the observation group received enteral and parenteral nutrition, micro-feeding instead of fasting, tube feeding while taking non-nutritive sucking, the control group received evening feeding, fasting during feeding intolerance, feeding process without non-nutritive sucking.The weight and other growth indicators, the serum motilin and gastrin levels of 2 d, 7~9 d, 13~15 d after birth were monitored. Results 1)The increase time of weight, time reaching full enteral feeding and recovery time of birth weight of observation group were shorter[(7.28±6.25)d to(10.8±5.07)d, (11.16±4.32)d to(18.43±9.72)d, (8.21±3.72)d to (13.84±5.46)d], the days in hospital was shorter(16.82±2.2)d to (19.91±2.3)d, and the rate of extrauterine growth retardation was lower(40.30% to 65.38%), motilin levels of the babies who birth 2 d and 7~9 d were higher[(348.6±177.6)pg/mL to(246.3±95.6)pg/mL, (492.3±235.8)pg/mL to(342.2±141.5)pg/mL], gastrin levels of birth 13~15 d was higher[(75.2±12.9)pg/mL to(58.9±16.5)pg/mL], differences were statistically significant (P＜0.05).2) The differences of growth rate, and the gastrin levels of birth 2 d and 7~9 d had no statistically significant (P＞0.05). Conclusion Implementation of enteral and parenteral nutrition can effectively reduce incidence of extrauterine growth retardation.