Objective To explore the proportion and type of metabolic disorders in children with autism. Method Based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-Ⅳ) diagnostic criteria, 1 253 autistic children who had been diagnosed by Min Lusi metabolic analysis were chosen as research subjects from 2007 to 2011. Results In the 1 253 cases diagnosed as autistic children from 2007 to 2011, there were 204 cases of metabolic disorders, 16.3% of the total.In the 204 cases, there were 35 kinds of metabolic diseases. Conclusions The relationship between autism and metabolic disorders is positive.The most ten sensitive metabolic disorders aredouble carboxylic acid urine ketone sex, mild ketone double carboxylic acid urine, mild ketonuria urine, high lactose and galactose, mild non-ketogenic dicarboxylic acid in urine, high lysine, high cysteine, high methylmalonic acid and methylmalonic acidemia, high tetrathydroxy phenyllactic acid, high tris hydroxyacid, and tetrahydroxy phenylpyruric acid.For some treatable metabolic disorders, the rehabilitation efficacy may be improved to the children with autism by metabolic diseases treatment at the same time of rehabilitation training.
Key words
autistic children /
metabolic disorders /
sensitivity
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