Serum tPA and PAI-1 levels in autism children.

PENG Zhi-qing; ZHANG Lun; SUN Cai-hong; XIA Wei; WU Kun.

doi:10.11852/zgetbjzz2015-23-05-08

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Chinese Journal of Child Health Care ›› 2015, Vol. 23 ›› Issue (5) : 468-471. DOI: 10.11852/zgetbjzz2015-23-05-08

Serum tPA and PAI-1 levels in autism children.

PENG Zhi-qing¹, ZHANG Lun^{1, 2}, SUN Cai-hong³, XIA Wei³, WU Kun¹.

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Abstract

Objective To evaluate the serum tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1(PAI-1) levels of children with autism and evaluate the relationship between tPA and PAI-1 levels of autism. Methods According to "Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-Ⅳ)" and "The Children Autism Rating Scale (CARS)", 40 children were diagnosed as autistic cases and graded for the illness severity.40 healthy children were enrolled as control.Levels of cytokines in serum were quantified by an enzyme-linked immunosorbent.With a SPSS 20.0 statistical software, t test and ANOVA were used to analyse the statistical significant. Results Serum tPA level of the children with autism was lower than that of control (P<0.05).Serum PAI-1 level of the children with autism were significantly higher than that of the control children (P<0.05).According to the graded for the illness classification, the serum tPA level in the mild autism children had a decreased trend when compared with the children in the control group (P>0.05), the difference was not significant.The tPA level in the severe autism children was significantly lower than that in control children (P<0.05).There was no significant difference in mild and severe autism children (P>0.05).Both of the PAI-1 levels of the mild and the severe autism children were significantly higher than that in control (P<0.05).There also was not statistically differences between the mild and severe autism children for the PAI-1 levels (P>0.05).The tPA and PAI-1 had no significant difference between male and female in both control and autism group (P>0.05). Conclusion The serum tPA level in children with autism is significantly lower than that in control, but serum PAI-1 of the levels is significantly higher than that in control, both may play an important role in the pathogenesis of autism.

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tissue-type plasminogen activator / plasminogen activator inhibitor-1 / autism / child / serum

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PENG Zhi-qing, ZHANG Lun, SUN Cai-hong, XIA Wei, WU Kun.. Serum tPA and PAI-1 levels in autism children.[J]. Chinese Journal of Child Health Care. 2015, 23(5): 468-471 https://doi.org/10.11852/zgetbjzz2015-23-05-08

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