Objective To discuss the correlation of fractional exhaled nitric oxide (FeNO) and peripheral blood eosinophil (EOS) in children with asthma,and to investigate the clinical significance of FeNO and EOS in asthmatic children,and to provide the basis for early diagnosis and effective treatment. Methods A total of 45 cases of children with asthma were collected from July 2012 to December 2013 in the pediatric ward and clinic of the Linqu County People's Hospital,26 cases of normal control group.FeNO and EOS were measured respectively. Results 1) The levels of FeNO and EOS in acute asthma group[(57.34±41.53) ppb],[(1.66±4.52)×10⁹/L]were significantly higher than those in remission group[(41.48±26.96) ppb),[(0.63±0.56)×10⁹/L]and control group[(16.14±6.37) ppb],[(0.08±0.07)×10⁹/L],the differences were statistically significant (P<0.05).2)The levels of FeNO and EOS in remission asthma group were still higher than those of the control group,the differences were statistically significant (P<0.05).3)The level of FeNO in asthma group was positively correlated with the level of peripheral blood EOS (r=0.71,P<0.05). Conclusions Increased FeNO levels in children with asthma had a good correlation with EOS,which can indirectly reflect the level of airway eosinophilic inflammation,and the sensitivity is higher than EOS.The remission of asthma airway inflammation is still need to be anti-inflammatory treatment.The combined use of FeNO and EOS can assess the severity and adjust the treatment plan in clinic.