Objective To explore the effect of the expression of n-3 PUFA supplementation on pulmonary ventilation function,exhaled nitric oxide(FeNO) and cytokine production of children with asthma. Methods Children with asthma were randomly divided into two groups:treatment group (46 cases) and conventional group (26 cases).The conventional group was treated with conventional methods.The treatment group was given additional n-3PUFA supplementation besides conventional treatment.FEV1%,PEF%,FeNO and IL-4,IL-5,IFN-γ,TGF-β1 in the serum were measured before and after the treatmen. Results Compared with conventional group,the FEV1%,PEF% increased significantly (P<0.01) and FeNO decreased (P<0.01) among treatment group after the treatment.The concentration of IL-4,IL-5,TGF-β1 decreased,and that of IFN-γ increased in the serum of asthma children with before and after the treatment. Conclusion The n-3PUFA can remarkably improves ventilation,reduce airway inflammation in children with asthma.
Key words
n-3PUFA /
exhaled nitric oxide /
cytokines /
children asthma
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