Objective To observe the curative effect of scalp acupuncture and comprehensive education rehabilitation on children with autistic spectrum disorders (ASD). Methods A total of 116 cases of 2～6 years old children with ASD were divided into two groups,the control group with comprehensive education rehabilitation therapy,and the observation group with comprehensive education rehabilitation on the basis of application of scalp acupuncture(1 time/d),and the patients rested for 2 days every weeks.Effects were evaluated with Childhood Autism Rating Scale( CARS),Autism Behavior Checklist(ABC),Infant-Junior Middle school Social Adaptive Capacity Scale(SM),the Children's Mental Development Diagnosis Scale( 0~6 years old) at begin and after 6 months. Results After 6 months of treatment,the scores in CARS and ABC were lower apparently in observation group than those before treatment (both P<0.01),and the scores in CARS and ABC were lower than those in control group (both P<0.01);In observation group,the scores in SM and DQ were improved obviously after treatment (P<0.01),which were all higher than those in control group ( both P<0.01). Conclusion Scalp acupuncture combined with comprehensive education rehabilitation can significantly improve the therapeutic effect of the autistic spectrum disorders,effectively relieve childhood autism symptoms and enhance the developmental quotient and social adaptive ability.