Objective To assess the efficacy and safety of Topiramate and Haloperidol in the treatment of children with tic disorder. Methods The randomized controlled trials about children with tic disorder treated with Topiramate and Haloperidol published before January 2014,were searched in the PubMed,EBSCO,EMbase,Ovid,Cochrane Library,CNKI,Wanfang Date and VIP.Some published references were hand-searched.Two reviewers independently screened the literatures,extracted the data and evaluated quality.Meta analysis was conducted by Revman 5.1 and Stata 12.0 software. Results Sixteen RCTs involving 1 148 patients [treatment group (n=609);control group (n=539)] were included.Ages were 2.5 to 17 years old.Meta-analysis of motor tic scores,vocal tic scores,comprehensive damage scores and severity scores indicated the treatment group was superior to the control group [Mean difference (Inverse Variance,Random) -13.58 to -4.58 (95%CI:-22.44~-1.32)].Meta-analysis of the number of tic symptom improvement showed the treatment group was superior to the control group (OR=1.71,95%CI:1.22~2.39).Meta-analysis of the number of adverse events showed the treatment group was superior to the control group(OR=0.42,95%CI:0.24~0.75). Conclusion Topiramate has more advantage than haloperidol in the efficacy and safety for children with tic disorder,especially Tourette syndrome.
Key words
Topiramate /
Haloperidol /
children /
tic disorder /
Meta-analysis
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