Objective To evaluate effect of sublingual dermatophagoides farinae drops combined with standardized treatment in children with asthma. Methods A total of 110 children aged 6~14 years old with out acute exacerbation of mild - moderate allergic asthma from department of allergy of Fuzhou Children's Hospital from October to December in 2009 were selected and divided randomly into experimental group and control group of 55 cases each.The experimental group was given sublingual dermatophagoides farinae drops combined with inhaled corticosteroids standardized treatment,control group was given only inhalation therapy of hormone regulation.2 years of follow-up,the number of respiratory tract infections and asthma attacks,the children missed school days,the results of lung function FEV1%,FEF25%,FEF50% and inhaled corticosteroid dose were compared before and after treatment. Results 1) No significant difference was found in the pulmonary function (FEV1%,FEF25%,FEF50%) between the two groups before the treatment (P＞0.05);The pulmonary function indexes of the experimental group were significantly higher than the control group after treatment(P＜0.05);The pulmonary function indexes of the experimental group after treatment were significantly higher than those of before treatment (P＜0.05);2) The number of respiratory tract infections and asthma attacks,the children missed school days in experimental group significantly reduced than the control group after treatment (P＜0.05);3) The inhaled corticosteroid dose in experimental group significantly reduced than the control group after treatment (χ²=9.072,P=0.028). Conclusion The effector of sublingual dermatophagoides farinae drops standardized treatment combined inhaled hormone is better than single treatment with inhaled corticosteroid.