Objective To investigate the effectiveness of INtubate-SURfactant-Extubate to CPAP (INSURE) method in premature infants with respiratory distress syndrome(NRDS). Methods A total of 127 prematures with NRDS from January 2011 to December 2012 were recruited,and data were collected retrospectively.Early outcomes(the PS repeatment,pneumorrhagia,air leak syndrome,PPHN,PDA),late outcome(BPD,ROP,IVH,PVL),complications related with infection(septicemia,NEC) as well as prognosis were compared between two groups. Results There was no statistically difference in general conditions between two groups (P>0.05).The second PS need,pneumorrhagia and air leak syndrome as well as PPHN were significantly decreased in INSURE group (P<0.05).INSURE group had less cases with infectious diseases as septicemia (P<0.05).There was no statistically difference (P>0.05) in the late outcomes such as BPD,ROP,IVH and PVL between two groups.The prognosis such as cure rate and mortality showed no difference in two groups (P>0.05). Conclusions Compared with MV,INSURE can improve the early outcome of NRDS by alleviating NRDS severity,reducing the second PS need,decreasing pneumorrhagia,air leak symdrome and PPHN.It also lowers septicemia.It shorts the total oxygen therapy time,without increasing the occurance of BPD,ROP,IVH,PVL and the mortality.
Key words
INSURE method /
neonatal respiratory distress syndrome /
clinical study
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References
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