Objective To investigate the correlation between early arterial blood gas analysis and brain injury in preterm infants,and further to provide reference for early diagnosis and intervention of it. Methods The preterm infants with arterial blood gas analysis results in 1 hour after birth in our hospital from Jan.2010 to Dec.2011 were collected.51 infants diagnosed as brain injury were selected as case group,and each case were matched with 3 normal infants with same gestational age as control group.PH,PaO2,PaCO2,BE between the two groups were compared,and the correlation analysis on their relationship with brain injury were carried out. Results The incidence of brain injury in preterm infants was 16.4%,IVH and PVL were 13.4% and 3.0% respectively.PH(7.23±0.13),PaO2(68.53±30.85),BE(-6.50±3.93)from the brain injury group were significantly lower than those from the control group (7.32±0.08,81.05±29.19,-4.04±3.66)(all P＜0.01),while PaCO2(50.16±14.13) was significantly higher than that of the control group(44.30±10.27)(P＜0.01).Further research,when PH<7.15,PaO2<35 mmHg,PaCO2>65 mmHg,BE<-10 mmol/L,the incidence of brain injury in preterm infants increased.And logistic analysis showed that PH<7.15,PaO2<35 mmHg,PaCO2>65 mmHg were closely related to brain injury in preterm infants,values of OR (95%CI) were 0.14(0.03～0.68),0.04(0.01～0.68),0.06(0.01～0.55) respectively. Conclusions Early arterial blood gas analysis are closely related to brain injury in preterm infants.
Key words
preterm infants /
brain injury /
early arterial blood gas
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