Expression and significance of serum miRNA-21 control HIF-1α in newborn with asphyxia.

CHEN Hui-jun; YANG Ting-tong

doi:10.11852/zgetbjzz2015-23-01-10

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Chinese Journal of Child Health Care ›› 2015, Vol. 23 ›› Issue (1) : 32-34. DOI: 10.11852/zgetbjzz2015-23-01-10

Expression and significance of serum miRNA-21 control HIF-1α in newborn with asphyxia.

CHEN Hui-jun¹,YANG Ting-tong²

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Abstract

Objective To study the expression and significance of serum miRNA-21 and hypoxia inducible factor-1α (HIF-α) in newborns with asphyxia. Methods A total of 78 newborn infants were recruited in the study,including 49 newborn infants with asphyxia and 29 cases without asphyxia.In 24~48 h after birth,the serum miRNA-21 and hypoxia inducible factor-1α (HIF-1α) were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Result The levels of serum miRNA-21 and HIF-1α in newborn infants with asphyxia were high than those of control group (P<0.05). Conclusions Serum miRNA-21 plays a role on the hypoxic brain damage after asphyxia by acting on the target genes of HIF-1α.The serum expression of miRNA-21 can be used as a marker in the early diagnosis of hypoxic brain damage after asphyxia.

Key words

asphyxia / newborn infant / miRNA-21 / hypoxia inducible factor-1α / quantitative real-time polymerase chain reaction

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CHEN Hui-jun,YANG Ting-tong. Expression and significance of serum miRNA-21 control HIF-1α in newborn with asphyxia.[J]. Chinese Journal of Child Health Care. 2015, 23(1): 32-34 https://doi.org/10.11852/zgetbjzz2015-23-01-10

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